TABLE 4.

Estimated pharmacokinetic parameters of gentamicin in rabbit serum following implantation of ECM envelope

Parameters	Value
C max	59.96 mg/L
T max	1.00 h
Kβ	0.41 h−1
Kα	4.47 h−1
T β 1/2	1.67 h
Tα 1/2	0.15 h
[AUC]0 10h	88.90 mg•h/L
[AUC]0 ∞	93.07 mg•h/L

[AUC]₀ ^10h, area under serum concentration‐time curve from time 0 to 10 h; [AUC]₀ ^∞, area under serum concentration‐time curve from time 0 to infinity; C_max, maximum serum concentration; K_β, terminal rate constant; K_α, absorption rate constant; T^β _½, terminal half‐life; T^α _½, absorption half‐life; T_max: time to maximum concentration.