Table 2.
Cohort studies on heavy menstrual bleeding in women with inherited platelet receptor defects
| Author, year | Study design, study population, HMB definition | Results | HMB treatment | |
|---|---|---|---|---|
| HMB in women with inherited platelet receptor defects | Awidi (1992)87 |
Prospective cohort study 25 women with GT HMB definition unknown |
HMB incidence unclear | 48% (12/25) of women together received 140 units of blood and 80 units of platelets for treatment of HMB during a total follow‐up of 145 years. In 57.1% (4/7) of women that used OCPs, HMB was successfully managed, whereas in 42.9% (3/7), the need for transfusions was unchanged |
| Vijapurkar (2009)86 |
Prevalence of HMB among Indian women with rare bleeding disorders HMB defined as > 80 mL blood loss per menstruation lasting more than seven days |
HMB was reported in 66.7% (2/3) of women with BSS and in 77.3% (17/22) of women with GT. In two women, HMB led to iron deficiency anaemia despite the use of OCPs | Management mainly included tranexamic acid and OCPs. Both women with BSS received platelet and blood transfusions in combination with OCPs. 11.8% (2/17) of women required more than a hundred units of platelets and whole blood transfusions over the course of more than twenty years, one of whom was later efficaciously treated with endometrial ablation. | |
| Toogeh (2010)82 |
Retrospective cohort study 49 Iranian women with BSS HMB definition unknown |
22.4% (11/49) of women had had at least one episode of HMB. | Not described | |
| Toogeh (2004) 4 |
Retrospective cohort study 132 Iranian women of reproductive age diagnosed with GT HMB definition unknown |
12.9% (17/132) of women had had at least one episode of HMB | Not described | |
| Inherited platelet receptor defects in women with HMB | Kushwaha (2017)83 |
Prospective study 104 women who presented at the emergency department with complaints of menorrhagia in whom local pelvic pathology and hormonal disorders had been eliminated as a cause HMB definition not provided |
Identified seven women with GT (6.7%) and one woman with BSS (1.0%) | Not described |
| Cakı Kılıç (2013) 85 |
Sixty women of reproductive age women who presented at the gynaecology and haematology outpatient and emergency care units HMB defined as > 80 mL blood loss per menstrual cycle |
Identified two women with GT (3.3%) and three women with BSS (5.0%) | Detailed information on HMB treatment was not available, except that all included women received oral tranexamic acid and none of them underwent endometrial ablation or hysterectomy | |
| Hutspardol (2010) 84 |
28 adolescents with a history of menorrhagia HMB defined as > 80 mL blood loss per menstrual cycle |
One woman with GT (3.6%) and two women with BSS (7.1%) | HMB was successfully treated using a combination of OCPs and tranexamic acid |
Abbreviations: GT, Glanzmann thrombasthenia; BSS, Bernard‐Soulier syndrome; HMB, heavy menstrual bleeding; OCP, oral contraceptive pills.