Figure 1.

Structural design of an amphiphilic polyphenylene dendron by desymmetrization of amphiphilic dendrimer PPD3. By the employment of a clickable ethynyl group, the introduction of a second function by post‐modification was achieved. The amphiphilic pattern of these dendron‐conjugates interacts with biological structures like proteins and was verified by interactions of dendron‐coated liposomes with blood serum proteins (protein structures: PDB‐files 4NHH,24 1FZC,25 5Z0B26) as well as binding to Ad5 for re‐direction into CAR‐negative cells.