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. 2020 Feb 3;59(14):5712–5720. doi: 10.1002/anie.201913708

Figure 4.

Figure 4

Dendron‐Ad5 complex formation leads to EGFP‐transduction in CAR‐negative cells. A) Coating of Ad5 by dendrons and the potential for cellular uptake into CAR‐negative cells resulting in gene transduction. B) TEM images show binding of dendrons to Ad5 (Ad5: Dendron=1: 100k). C) Fluorescent microscopy image of EGFP‐transduction in CAR‐negative CHO‐K1 cells (Ad5: Dendron=1: 500k). D) Flow cytometry of CHO‐K1 cells incubated with Ad5‐dendron complexes with ratios of Ad5: Dendron=1:20k‐1:500k and Ad5: PPD3=1:5k‐1:125k, respectively (n=3, * represents p‐value <0.05, ** represents p‐value <0.01, *** represents p‐value <0.001, **** represents p‐value <0.0001).