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. 2020 Mar 12;3(2):334–344. doi: 10.1021/acsptsci.0c00013

Figure 2.

Figure 2

CTEP treatment for 24, but not 36, weeks improved performance of APPswe/PS1ΔE9 mice in the Morris Water Maze and Morris Water Maze with reversal. Mean ± SEM of (A) escape latency, (B) path length, (C) swim speed obtained for Morris Water Maze acquisition phase, and (D) mean ± SD of time spent in the target quadrant during the probe trial following a 24 week or 36 week treatment with either vehicle or CTEP (2 mg/kg) of age matched wild-type (wt) and APPswe/PS1ΔE9 (APP) mice. Mean ± SEM of (E) escape latency, (F) path length, and (G) swim speed obtained for Reversal Morris Water Maze acquisition phase, and (H) mean ± SD of time spent in the target quadrant during the probe trial following a 24-week or 36-week treatment with vehicle or CTEP of age matched wt and APP mice (n = 9–11). *P < 0.05 versus age-matched, vehicle-treated wt mice. Statistical significance was assessed by two-way ANOVA and Fisher’s LSD comparisons. Mice were excluded from analysis due to spontaneous death.