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. 2020 Mar 12;3(2):334–344. doi: 10.1021/acsptsci.0c00013

Figure 4.

Figure 4

ZBTB16 autophagic pathway was activated in 12 month old APPswe/PS1ΔE9 mice by 24 weeks of CTEP treatment. Representative Western blots and quantification of folds change in (A) GSK3β-pS9, (B) ZBTB16, (C) ATG14, and (D) p62 with the corresponding loading controls in brain lysates from age matched wild-type (wt) and APPswe/PS1ΔE9 (APP) mice after either a 24 week or 36 week treatment with either vehicle or CTEP (2 mg/kg). GSK3β-pS9 was normalized to total GSK3β, ZBTB16, ATG14, and p62 were normalized to vinculin (n = 5 for each group). Values represent mean ± SD and are expressed as a fraction of the age matched, vehicle treated wt value. *P < 0.05 versus age-matched, vehicle-treated wt values. Statistical significance was assessed for GSK3β-pS9, ATG14, and p62 after 24 weeks of treatment with Kruskal–Wallis test and by two-way ANOVA and Fisher’s LSD comparisons for the rest of the panels.