Figure 6.

CTEP treatment for 24, but not 36, weeks reduced neuroglial activation in APPswe/PS1ΔE9 mice. Quantification of the number of (A) Iba1 and (B) GFAP positive cells in cortical brain slices from age-matched wild-type (wt) and APPswe/PS1ΔE9 (APP) mice following a 24 week or 36 week treatment with either vehicle or CTEP (2 mg/kg). Data represent the quantification of five different 900 μm² regions in six cortical slices derived from four independent mouse brains for each group and expressed as the mean ± SD. The asterisk (∗) denotes significant difference at P < 0.05. Statistical significance was assessed by two-way ANOVA and Fisher’s LSD comparisons.