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. 2020 Feb 26;3(2):246–262. doi: 10.1021/acsptsci.9b00083

Figure 7.

Figure 7

Structural models showing the impact of individual amino acid substitutions across αCGRP, AM, and AM2. (A) αCGRP at the CGRP receptor,19 (B) AM at the AM1 receptor, (C) AM at the AM2 receptor, and (D) AM2 at the AM2 receptor.34 Results for AM are cAMP results from this paper at the AM1 receptor (Cos7 and HEK293S) and AM2 receptor (Cos7), results for AM2 and αCGRP are derived from previous publications (Tables S23 and S24). In this image CLR is gray, RAMP1 is pink, RAMP2 is light blue, RAMP3 is gold, and peptides are blue. Effects of substitutions are colored according to the legend.