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. 2020 Mar 30;23(4):101015. doi: 10.1016/j.isci.2020.101015

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© 2020 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

MCL-1 Inhibition Causes Cell Death in hiPSC-CMs that is Blocked by a Necrosis Inhibitor

(A and B) hiPSC-CMs were treated with increasing doses of S63845 (A) or AMG-176, and AZD5991 (B) for 48 h before caspase activity was measured by CaspaseGlo 3/7 assay (Promega). Quantification shows results from at least three independent experiments performed in duplicate and were normalized to DMSO control. Graphs represent mean ± SEM.

(C) CellTiter-Blue assay (Promega) was used to assess cell viability in hiPSC-CMs. p values were calculated by one-way ANOVA. Data was quantified from three independent experiments performed in triplicate. Boxplots show median with Tukey whiskers.

See also Figure S5.