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. 2020 Mar 18;35(1):805–814. doi: 10.1080/14756366.2020.1740694

Table 2.

Biological evaluation in vitro.

Product IC50 value (μM)
AChE inhibitory activity BuChE inhibitory activity MAO-B inhibitory activity Antioxidant activity
1 50.58 ± 3.12 >200 61.26 ± 0.79 13.28 ± 0.27
2 4.15 ± 1.02 24.92 ± 0.96 14.67 ± 0.78 >100
3 80.48 ± 3.41 >200 298.43 ± 5.4 11.78 ± 0.18
4 0.74 ± 0.06 >200 383.45 ± 5.08 33.07 ± 1.45
5 0.48 ± 0.05 >200 22.48 ± 0.22 5.51 ± 0.20
6 24.38 ± 1.21 >200 48.59 ± 2.02 /
7 0.52 ± 0.07 32.92 ± 0.76 91.13 ± 0.70 2.62 ± 0.21
8 9.24 ± 0.62 >200 40.62 ± 1.92 5.96 ± 0.14
9 0.35 ± 0.03 >200 354.19 ± 5.05 17.17 ± 0.58
10 28.65 ± 1.44 >200 493.39 ± 7.10 13.89 ± 0.11
11 48.24 ± 0.34 >200 38.61 ± 0.42 11.22 ± 0.24
12 5.25 ± 0.44 180.91 ± 1.48 22.85 ± 0.73 1.60 ± 0.10
13 0.28 ± 0.01 9.91 ± 0.48 11.24 ± 0.72 5.33 ± 0.08
14 3.37 ± 0.17 128.33 ± 4.65 69.65 ± 1.26 5.11 ± 0.13
15 2.54 ± 0.19 >200 215.22 ± 2.27 32.58 ± 0.42
16 4.07 ± 0.19 >200 >500 18.01 ± 0.48
17 42.26 ± 4.01 >200 82.68 ± 1.31 29.17 ± 0.31
18 123.88 ± 2.17 >200 180.34 ± 1.32 64.48 ± 1.29
19 36.50 ± 0.51 >200 145.56 ± 1.83 12.56 ± 0.14
20 0.089 ± 0.01 >200 149.21 ± 3.39 42.56 ± 2.58
21 2.38 ± 0.20 145.89 ± 3.05 >500 5.35 ± 0.33
22 2.03 ± 0.09 >200 30.27 ± 0.65 6.44 ± 0.12
23 25.96 ± 1.26 >200 43.89 ± 1.26 11.94 ± 0.16
Donepezil 0.059 ± 0.003 4.67 ± 0.16    
Rasagiline     0.104 ± 0.002  
Ascorbic acid       7.69 ± 0.10

Each value represents the mean ± SD (n = 3).