Table 3.

TOPKAT prediction results

Compound	Mutagenicity	TD50 value (mg/kg)		LD50 value(g/kg)
		Carcinogenicity (Mouse)	Carcinogenicity (Rat)	Acute oral toxicity (Rat)
1	0.495	184	7.9	0.719
2	0.535	184	7.9	0.998
3	0.631	89	1.49	0.784
4	0.586	89	2.08	1.95
5	0.569	83.6	7.11	0.842
6	0.406	252	11.8	2.62
7	0.583	209	5.81	0.488
8	0.571	127	5.81	0.732
9	0.522	100	2.09	2.89
10	0.528	100	2.09	1.62
11	0.211	268	6.87	1.76
12	0.522	268	8.55	1.83
13	0.533	268	8.55	1.75
14	0.274	268	9.24	1.37
15	0.323	106	1.64	1.76
16	0.33	106	2.08	1.73
17	0.443	106	2.08	3.63
18	0.474	106	1.49	1.73
19	0.516	128	2.19	2.75
20	0.293	198	6.11	2.59
21	0.336	158	3.89	1.07
22	0.292	282	8.46	1.95
23	0.275	75.4	0.994	1.67
Donepezil	0.22	99.8	1.56	0.392
Rasagiline	0.598	94.9	20.2	0.427