Table 3.
Baseline of the 75 Blood Samples Collected Before Treatments.a
| CTCs | MCTCs | ||||||
|---|---|---|---|---|---|---|---|
| Indicators | N (%) | Positive, N (%) | Negative N (%) | P | Positive, N (%) | Negative N (%) | P |
| Number | 68 | 7 | 64 | 11 | |||
| Age | |||||||
| Mean ± SD | 49.00 ± 11.99 | ||||||
| Range (years) | 22-80 | ||||||
| Gender | .498 | .523 | |||||
| Male | 58 (77.3) | 52 (89.7) | 6 (13.3) | 49 (84.5) | 9 (15.5) | ||
| Female | 17 (22.7) | 16 (94.1) | 1 (5.9) | 15 (88.2) | 2 (11.8) | ||
| Smoking | .362 | .122 | |||||
| Yes | 21 (28.0) | 20 (95.2) | 1 (4.8) | 20 (95.2) | 1 (4.8) | ||
| No | 54 (72.0) | 48 (88.9) | 6 (11.1) | 44 (81.5) | 10 (18.5) | ||
| TNM stage | .631 | .758 | |||||
| I | 5 (7.1) | 5 (100.0) | 0 | 4 (80.0) | 1 (20.0) | ||
| II | 1 (1.4) | 1 (100.0) | 0 | 1 (100.0) | 0 | ||
| III | 5 (7.1) | 5 (100.0) | 0 | 5 (100.0) | 0 | ||
| IV | 59 (84.3) | 53 (89.8) | 6 (10.2) | 50 (84.8) | 9 (15.2) | ||
| T | .568 | .504 | |||||
| 1 | 9 (12.9) | 9 (100.0) | 0 | 8 (88.9) | 1 (11.1) | ||
| 2 | 17 (24.3) | 16 (94.1) | 1 (5.9) | 16 (94.1) | 1 (5.9) | ||
| 3 | 22 (31.4) | 20 (90.9) | 2 (9.1) | 19 (86.4) | 3 (13.6) | ||
| 4 | 22 (31.4) | 19 (86.4) | 3 (13.6) | 17 (77.3) | 5 (22.7) | ||
| N | .311 | .577 | |||||
| 0 | 6 (8.6) | 6 (100.0) | 0 | 5 (83.3) | 1 (16.7) | ||
| 1 | 11 (15.7) | 9 (95.1) | 2 (18.2) | 9 (81.8) | 2 (18.2) | ||
| 2 | 41 (58.6) | 39 (95.1) | 2 (4.9) | 37 (90.2) | 4 (9.8) | ||
| 3 | 12 (17.1) | 10 (83.3) | 2 (16.7) | 9 (75.0) | 3 (25.0) | ||
| M | .518 | .678 | |||||
| 0 | 63 (90.0) | 57 (90.5) | 6 (9.5) | 54 (85.7) | 8 (14.3) | ||
| 1 | 7 (10.0) | 7 (100.0) | 0 | 6 (85.7) | 1 (14.3) | ||
| Metastasis | .401 | .667 | |||||
| Yes | 65 (90.3) | 59 (90.8) | 6 (9.2) | 56 (86.2) | 9 (13.8) | ||
| No | 5 (9.7) | 5 (100.0) | 0 | 6 (85.7) | 1 (14.3) | ||
| Distant | .366 | .693 | |||||
| Yes | 8 (11.1) | 0 | 8 (100.0) | 6 (85.7) | 1 (14.3) | ||
| No | 64 (88.9) | 58 (90.6) | 6 (9.4) | 55 (85.9) | 9 (14.1) | ||
| Lymph node | .366 | .693 | |||||
| Yes | 64 (88.9) | 58 (90.6) | 6 (9.4) | 55 (85.9) | 9 (14.1) | ||
| No | 8 (11.1) | 8 (100.0) | 0 | 7 (87.5) | 1 (12.5) | ||
| Relapse | .816 | .72 | |||||
| Yes | 2 (2.8) | 2 (100.0) | 0 | 2 (100.0) | 0 | ||
| No | 71 (97.3) | 64 (90.1) | 7 (9.9) | 60 (84.5) | 11 (15.5) | ||
Abbreviations: CTC, circulating tumor cells; MCTC, the CTC that were positive for mesenchymal biomarkers including biphenotypic CTC and mesenchymal CTC.
a Fisher exact test and Pearson χ2 test.