Table 7.
Multivariate Cox Regression Analysis of CTCs, FN1 Expression, and Patient Survival.
| Univariate Analysis | Multivariate Analysis | |||
|---|---|---|---|---|
| Survival Factors | HR (95% CI) | P | HR (95% CI) | P |
| Associated with PFS | ||||
| Total CTC (>9 vs ≤9/5 mL) | 1.620 (0.699-3.758) | .261 | 1.478 (1.133-3.127) | .259 |
| MCTC (>5 vs ≤5/5 mL) | 1.414 (0.747-2.677) | .288 | 1.570 (0.600-4.108) | .358 |
| Therapy | .009 | .0001 | ||
| Chemoradiotherapy vs Chemotherapy alone | 0.681 (0.349-1.327) | .184 | 0.264 (0.142-0.490) | .0001 |
| Chemoradiotherapy vs Radiotherapy alone | 0.615 (0.302-1.640) | .259 | 0.506 (0.227-1.127) | .095 |
| FN1 highly expressed MCTC (>1 vs ≤2) | 3.173 (1.257-8.009) | .015 | 1.251 (1.068-1.465) | .006 |
Abbreviations: CI, confidence interval; CTC, circulating tumor cell; FN1, fibronectin 1; HR, hazard radio; MCTC, mesenchymal CTCs; PFS, progression-free survival.