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. 2020 Apr 14;13:59. doi: 10.1186/s13041-020-00591-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — GO functional and KEGG pathway enrichment analysis of DEGs. a-c Separate GO enrichment analysis was carried out with “Goatools” using Fisher’s exact test and Benjamini-Hochberg was used to multiple testing corrections. The up-regulated and down-regulated genes were classified into different functional categories according to the GO term enrichment analysis for behavior related biological process, such as “Locomotion”, “Learning and memory” related biologic processes were enriched (a), cell death related biologic process, such as “Programmed cell death” related biologic processes were enrichment (b), Immune response related biologic process, such as “Immune response” related biologic processes were enrichment (c). d KEGG signing pathway enrichment analysis of differential expression genes. KEGG enrichment analysis was performed with “KOBAS 2.0” using Fisher’s exact test and Benjamini-Hochberg was used to multiple testing correction. The “Immune system”, “Cell growth and death” related pathway significantly enriched. Adjusted p value < 0.05 represents GO term or KEGG signing pathway significantly enriched. Rich factor means the ratio of enriched genes in background genes. The larger value of rich factor, the more enrichment of GO term or KEGG signing pathway. Count indicates the number of genes and “padj” means adjusted p value