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. 2020 Apr 14;18:29. doi: 10.1186/s12958-020-00584-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — a: HE staining of ovary and uterus(100×). Compared with the normal group, the number of primordial follicles and primary follicles in each cold group increased significantly. The diameter of granulosa layer and theca cell layer of ovary decreased obviously. In the cold stimulation groups, the lumen of uterus was narrow, and the lumen epithelium of endometrium was irregular papillary. b: Comparison of ovarian follicle diameter in each group, values are means±SD(n = 3), p < 0.01^a vs control, p < 0.01^c vs cold 7d. c: Comparison of endometrial epithelial height in each group, values are means±SD(n = 3), p < 0.01^a vs control. d: Comparison of ovarian index and uterine index in each group, values are means±SD(n = 3), p < 0.01^a vs control