Table 3:

Mediation Analysis

Total Effect		P-Value	Direct Effect	P-Value	Indirect Effect	P-Value	Proportion Mediated by Cardiovascular Complications
Mortality Within Two Years
Hazard ratio	1.51 (1.05 – 2.06)	0.024	0.92 (0.75 – 1.12)	0.38	1.21 (1.00 – 1.46)	0.047	80%
Mortality Between 7–30 Days
Hazard ratio	2.29 (1.18 – 4.41)	0.011	0.68 (0.46 – 1.02)	0.060	1.99 (1.34 – 2.95)	0.0007	87%
Mortality During First Hospitalization
Odds ratio	1.72 (1.15 – 2.62)	0.028	0.84 (0.60 – 1.18)	0.32	1.35 (1.25 – 1.46)	< 0.0001	78.5%

^*The mediator is at least one in-hospital cardiac complication within the first 30 days after the initial procedure (and prior to hospital discharge). The hazard ratios, odds ratios, and 95% confidence intervals represent the effect of complete repair (vs. staged repair).