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. Author manuscript; available in PMC: 2020 Apr 14.
Published in final edited form as: Brain Behav Immun. 2019 Jul 17;81:545–559. doi: 10.1016/j.bbi.2019.07.015

Fig. 3.

Fig. 3.

Chronic elevation of autoantibodies against 3-PBA-albumin in plasma of PB + PER mice, in veterans with GWI and in farm workers exposed to pyrethroids. Western Blot showed that control mice had no cross-reactivity to 3-PBA-albumin or albumin alone, but cross-reactivity in PB + PER mice plasma was observed for 3-PBA-albumin at 1.5-, 3- and 7-months post-exposure in PB + PER mice (n = 4 or 5/group). (B) Autoantibodies against 3- PBA-albumin were detected in 12 out of 14 veterans with GWI and 1 out of 10 control GW veterans. (C) Immunoreactivity of plasma with 3- PBA-albumin was observed in 5 out of 5 pyrethroid-exposed farm workers or ate pyrethroid tainted fruits and vegetables (as confirmed using 3-PBA measurements in urine), and a lack of immunoreactivity in controls in whom urine 3-PBA was undetected.