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. 2020 Apr 7;10:383. doi: 10.3389/fonc.2020.00383

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Copyright © 2020 Wang, Wang, Wu, Li, Huang, Zhou and Cui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Western blot analysis of proteins related to the EGFR signal pathway, including EGFR, p-EGFR, PI3K, p-PI3K, Akt, p-Akt, mTOR, p-mTOR, IKKα, IκBα, NFκB p65, MAPK, and p-MAPK. (A) Western blot images. β-Actin is used as a loading control for total protein, and histone H3 is used as a loading control for nuclear proteins. CTX, cetuximab treatment; RES, resveratrol treatment. The full-length blots are shown as Figures S7C,D. (B) Relationship between the EGFR signaling pathway and Cx43 (1, 14, 15). Cetuximab inhibits the binding reaction of EGF to EGFR, which inhibits the whole EGFR signaling pathway. Akt, a key molecule in this pathway, interacts with Cx43. Resveratrol increases Cx43 expression and phosphorylation.