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. 2020 Apr 7;10:383. doi: 10.3389/fonc.2020.00383

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Copyright © 2020 Wang, Wang, Wu, Li, Huang, Zhou and Cui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of tumor growth by cetuximab and resveratrol. CTX, cetuximab-treated mice; RES, resveratrol-treated mice. (A) The subcutaneous tumor model was created by parental, control-shRNA, or Cx43-shRNA-transfected cells. Each group contains five Balb/c mice for CT26 or nu/nu nude mice for HCT116. These mice were then treated with cetuximab and/or resveratrol for 14 days before sacrificed. Tumors were removed, and weight was measured using electronic balance. (B) Columns represent mean ± SEM volume from five tumors. Groups “CTX,” “RES,” and “CTX+RES” were compared with group “No treated” using one-way ANOVA. Blue *P < 0.05 represents a significant difference. Group “CTX+RES” was compared with group “CTX” and “RES” using one-way ANOVA. Yellow *P < 0.05 represents a significant difference.