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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Biochim Biophys Acta Mol Cell Res. 2020 Feb 19;1867(6):118688. doi: 10.1016/j.bbamcr.2020.118688

Figure 1. The human apoptotic caspases.

Figure 1.

A schematic representation of the domain organization of the human apoptotic caspases is shown. The caspases are divided into the initiator caspases and the executioner caspases. Each caspase comprises a prodomain and a large and small catalytic subunit. Initiator caspases have long prodomains containing the protein:protein interaction motifs, caspase recruitment domain (CARD) or death effector domain (DED), as indicated. The cleavage sites for each caspase are depicted with red arrows.