Table 2.

Binary and multivariate logistic regression analysis for fibrinogen level (continuous variable) for pathological outcomes when adjusting for preoperative confounders

Adverse pathological outcomes	Adjusted ORa	95% CI	P
High-grade disease	1.71	1.36–2.13	<0.001
High pT stage (≥ pT3)	1.69	1.40–2.04	<0.001
Lymph node involvement	1.47	1.18–1.84	0.001
LVI	1.30	1.08–1.57	0.007
Sessile carcinoma	1.45	1.19–1.78	<0.001
CVH	1.35	1.13–1.61	0.001
PSM	1.38	1.05–1.80	0.021

^aAdjusting for age (continuous), gender, BMI (continuous), smoking status, hydronephrosis, tumor side, tumor location, history of bladder cancer, multifocality, fibrinogen (continuous), platelet count (continuous), WBC count (continuous), ALP (continuous), LDH (continuous), NLR (continuous), and AGR (continuous). LVI: lymphovascular invasion; CVH: concomitant variant histology; PSM: positive surgical margins; pT: pathological tumor; OR: odds ratio; CI: confidence interval; BMI: body mass index; WBC: white blood cell; ALP: alkaline phosphatase; LDH: lactate dehydrogenase; NLR: neutrophil-to-lymphocyte ratio; AGR: albumin-to-globulin ratio