Supplementary Table 1.
Univariable Cox regression models predicting survival outcomes in patients with upper tract urothelial carcinoma
| Variables | Cancer-specific survival | Recurrence-free survival | OS | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
| Age (≥65 vs <65 years) | 0.848 (0.641–1.122) | 0.249 | 0.881 (0.696–1.115) | 0.293 | 0.966 (0.748–1.246) | 0.788 |
| BMI (>25 vs ≤25, kg/m2) | 0.848 (0.616–1.169) | 0.315 | 0.947 (0.729–1.230) | 0.681 | 0.917 (0.691–1.218) | 0.551 |
| Smoking status (former/current vs no) | 0.844 (0.615–1.159) | 0.294 | 0.864 (0.664–1.124) | 0.275 | 0.878 (0.662–1.164) | 0.364 |
| Gender (male vs female) | 0.824 (0.628–1.081) | 0.163 | 0.857 (0.682–1.076) | 0.184 | 0.876 (0.686–1.019) | 0.290 |
| Tumor side (right vs left) | 1.089 (0.830–1.428) | 0.538 | 1.063 (0.847–1.333) | 0.601 | 1.051 (0.824–1.341) | 0.687 |
| Bladder cancer status | 0.203 | 0.376 | 0.136 | |||
| No | Reference | Reference | Reference | |||
| Previous | 0.345 (0.085–1.391) | 0.134 | 0.903 (0.425–1.920) | 0.792 | 0.297 (0.074–1.198) | 0.088 |
| Concomitant | 1.205 (0.809–1.795) | 0.360 | 1.263 (0.901–1.770) | 0.176 | 1.198 (0.835–1.719) | 0.327 |
| Hydronephrosis (yes vs no) | 1.249 (0.938–1.664) | 0.128 | 1.401 (1.097–1.788) | 0.007 | 1.342 (1.035–1.740) | 0.026 |
| Tumor location | 0.556 | 0.508 | 0.675 | |||
| Pelvicalyceal | Reference | Reference | Reference | |||
| Ureteric | 1.005 (0.729–1.384) | 0.978 | 0.937 (0.715–1.229) | 0.639 | 0.941 (0.704–1.260) | 0.685 |
| Both | 1.217 (0.841–1.762) | 0.298 | 1.152 (0.842–1.577) | 0.377 | 1.118 (0.796–1.569) | 0.521 |
| Multifocality (yes vs no) | 1.059 (0.736–1.524) | 0.758 | 0.993 (0.727–1.358) | 0.967 | 0.971 (0.692–1.361) | 0.864 |
| Surgical approach (Laparoscopic vs Open) | 0.672 (0.485–0.932) | 0.017 | 0.858 (0.662–1.114) | 0.251 | 0.711 (0.529–0.956) | 0.024 |
| Tumor grade (high vs low) | 3.558 (2.305–5.492) | <0.001 | 2.278 (1.675–3.098) | <0.001 | 2.847 (1.992–4.070) | <0.001 |
| pT stage | <0.001 | <0.001 | <0.001 | |||
| pTis, pTa, pT1 | Reference | Reference | Reference | |||
| pT2 | 1.632 (0.966–2.757) | 0.067 | 1.502 (1.011–2.233) | 0.044 | 1.635 (1.045–2.558) | 0.031 |
| pT3 | 3.654 (2.372–5.629) | <0.001 | 2.797 (2.005–3.901) | <0.001 | 3.232 (2.222–4.702) | <0.001 |
| pT4 | 9.339 (5.921–14.729) | <0.001 | 6.936 (4.811–9.998) | <0.001 | 7.955 (5.327–11.881) | <0.001 |
| Lymph node status | <0.001 | <0.001 | <0.001 | |||
| pN0 | Reference | Reference | Reference | |||
| pNx | 1.496 (0.915–2.446) | 0.109 | 1.505 (1.013–2.235) | 0.043 | 1.507 (0.983–2.311) | 0.060 |
| pN+ | 6.124 (3.525–10.638) | <0.001 | 5.546 (3.484–8.831) | <0.001 | 5.361 (3.260–8.814) | <0.001 |
| LVI (yes vs no) | 2.726 (1.991–3.732) | <0.001 | 2.211 (1.676–2.917) | <0.001 | 2.511 (1.884–3.349) | <0.001 |
| Tumor size (>3 vs ≤3), cm | 1.985 (1.439–2.739) | <0.001 | 1.856 (1.425–2.418) | <0.001 | 1.983 (1.486–2.645) | <0.001 |
| PSM (yes vs no) | 2.319 (1.546–3.480) | <0.001 | 1.865 (1.290–2.694) | 0.001 | 2.118 (1.453–3.087) | <0.001 |
| Tumor architecture (Sessile vs Papillary) | 3.675 (2.480–5.447) | <0.001 | 2.500 (1.874–3.335) | <0.001 | 2.928 (2.114–4.055) | <0.001 |
| CVH (yes vs no) | 2.435 (1.825–3.248) | <0.001 | 2.045 (1.595–2.622) | <0.001 | 2.237 (1.722–2.906) | <0.001 |
| Adjuvant chemotherapy (yes vs no) | 0.963 (0.731–1.268) | 0.787 | 1.128 (0.896–1.420) | 0.304 | 0.889 (0.693–1.139) | 0.351 |
| WBC (≥8.3 vs <8.3, ×109 l−1) | 1.772 (1.305–2.407) | <0.001 | 1.455 (1.111–1.904) | 0.006 | 1.577 (1.189–2.092) | 0.002 |
| Platelet Count (≥230 vs <230, ×1099 l−1) | 2.111 (1.592–2.799) | <0.001 | 1.634 (1.276–2.091) | <0.001 | 1.711 (1.317–2.222) | <0.001 |
| ALP (≥90 vs <90, U l−1) | 1.782 (1.338–2.372) | <0.001 | 1.396 (1.092–1.785) | 0.008 | 1.497 (1.153–1.945) | 0.002 |
| LDH (> 220 vs ≤220, U l−1) | 1.613 (1.145–2.272) | 0.006 | 1.485 (1.109–1.989) | 0.008 | 1.553 (1.141–2.113) | 0.005 |
| NLR (≥2.5 vs <2.5) | 2.362 (1.749–3.190) | <0.001 | 1.854 (1.458–2.358) | <0.001 | 2.104 (1.617–2.737) | <0.001 |
| AGR (<1.45 vs ≥1.45) | 2.381 (1.781–3.183) | <0.001 | 1.818 (1.438–2.298) | <0.001 | 2.141 (1.656–2.767) | <0.001 |
| Fibrinogen (≥4.025 vs <4.025, g l−1) | 3.965 (2.998–5.243) | <0.001 | 2.855 (2.265–3.598) | <0.001 | 3.281 (2.559–4.206) | <0.001 |
LVI: lymphovascular invasion; pT: pathological tumor; CVH: concomitant variant histology; PSM: positive surgical margins; WBC: white blood cell; ALP: alkaline phosphatase; LDH: lactate Dehydrogenase; NLR: neutrophil-to-lymphocyte ratio; AGR: albumin-to-globulin ratio; HR: hazard ratio; BMI: body mass index; OS: overall survival