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Percent inhibition of HDAC8 by hydroxamate inhibitors.
| compound | concentration | ||
| 100 µM | 10 µM | 1 µM | |
| panobinostat (n = 4)a | 100 ± 0.0 | 100 ± 0.0 | 89 ± 13.4 |
| TOI1 (n = 4) | 100 ± 0.0 | 90 ± 21.1 | 44 ± 11.5 |
| TOI2 (n = 4) | 79 ± 8.1 | 75 ± 13.4 | 23 ± 26.9 |
| TOI3-rev (n = 4) | 89 ± 7.0 | 75 ± 26.9 | 37 ± 18.1 |
|
TOI4 (n = 4 @ 100 and 10 µM, n = 3 @ 1 µM) |
93 ± 8.1 | 89 ± 13.4 | 65 ± 21.4 |
| TCAb | 93 ± 14.0 | ||
an = number of replicates for the assay; btrichostatin A (TCA) as an inhibitor control.
