Figure 1.

Summary data from hyperglycemic clamps to assess glucose- and L-arginine-stimulated insulin secretion in participants with primary aldosteronism before treatment (●) and post-treatment (▽). Glucose was infused at a similar rate and glucose was maintained at 200mg/dL in both treatment periods. Insulin increased to a greater extent in participants post-treatment in response to hyperglycemia (A) and after L-arginine administration (B). C-peptide increased to a greater extent after treatment in response to hyperglycemia (C, D). The acute insulin response during the initial 0–10 minutes of the clamp is expanded (D). *p<0.05, **p<0.01, ***p<0.001. Group mean and SEM are shown.