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. Author manuscript; available in PMC: 2021 Apr 10.
Published in final edited form as: Circ Res. 2020 Feb 24;126(8):947–964. doi: 10.1161/CIRCRESAHA.119.316404

Figure 8. Predicted impact of sex as a biological variable with in silico 3D reconstructed left ventricular (LV) wedge based on Glukhov et al. 71 paced with before and after drug application.

Figure 8.

(A) Experimental data from normal human female (right) and male (left) left ventricle 71. (B) In silico reconstructed human tissues from these data from normal explanted heart at a pacing cycle length of 2000 ms (male – left and female – right). (C) The LV wedges were paced at basic cycle of 750 ms for 20 beats. The APD80 map was shown for male in the control condition (no drug) (left map in C) and following moxifloxacin (middle map) and dofetilide (right map) applications. Pseudo ECGs (the 20th beat) shows the effect of drug application on QT interval in the right panel. (D) Shown for female as in (C).