Skip to main content
. Author manuscript; available in PMC: 2020 Sep 2.
Published in final edited form as: Nat Chem. 2020 Mar 2;12(4):399–404. doi: 10.1038/s41557-020-0424-5

Table 1. |.

Exploration of reaction conditions that enables remote site-selective arylation of benzoazins.

graphic file with name nihms-1551699-t0004.jpg

10 mol% Pd(OAc)2, 20 mol% ligand, 1 equiv. 3-methyl isoquinoline, 1 equiv. template–MeCN, 1.5 equiv. NBE–CO2Me, 3 equiv. methyl 2-iodobenzoate, 3 equiv. AgOAc, 1 equiv. Ag2CO3, HFIP, 80 °C. The yield was determined by 1H NMR spectroscopy. T, template; HFIP, hexafluoro-2-propanol; Me, methyl group; Et, ethyl group; Ph, phenyl group; Ac, acetyl group; CN, cyano group.