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. Author manuscript; available in PMC: 2020 Sep 2.
Published in final edited form as: Nat Chem. 2020 Mar 2;12(4):399–404. doi: 10.1038/s41557-020-0424-5

Table 3. |.

Remote C7-arylation of tetrahydroisoquinolines.

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Aryl iodide = 1-iodo-2-nitrobenzene. 10 mol% Pd(OAc)2, 20 mol% Ac–Gly–OH, 1 equiv. tetrahydroisoquinolines, 1.5 equiv. NBE–CO2Me, 3 equiv. aryl iodide, 3 equiv. AgOAc, HFIP, 100 °C. For 4c and 4e, 20 mol% Pd(OAc)2 and 40 mol% Ac–Gly–OH were used. For each entry number (in bold), data were reported as isolated yield.