Table 3:

Unadjusted and adjusted^* outcomes by exposure status (N = 150,948)

	Unexposed	Typical	Atypical	Both
Hospitalizations	139,098	1,419	9,169	1,262
Death or cardiopulmonary arrest – n (%)	543 (0.4%)	36 (2.5%)	83 (0.9%)	28 (2.2%)
Unadjusted HR (95%CI)	Reference	2.9 (2.0 - 4.2)	1.1 (0.9 - 1.4)	2.1 (1.3 - 3.3)
Cox-Proportional Hazards Model Adjusted HR (95%CI)	Reference	1.6 (1.1 - 2.4)	1.1 (0.8 - 1.4)	1.3 (0.8 - 2.0)
Propensity Matched Analysis (n=4,233) HR (95%CI)	Reference	1.8 (1.1 - 3.0)	1.2 (0.7 - 2.0)	N/A
Delirium-only Cohort (n=7196) HR (95% CI)	Reference	1.9 (1.1 - 3.2)	0.9 (0.6 - 1.4)	1.4 (0.7 - 2.5)

^*All models adjusted for: demographics (age, gender, race); admission characteristic variables, including admitting department (medicine versus non-medicine), and time spent in the intensive care unit (ICU); delirium, dementia, insomnia; 28 additional medical comorbidities identified via ICD-9-CM and ICD-10-CM secondary diagnosis codes and Diagnosis Related Groups using Healthcare Cost and Utilization Project Comorbidity Software based on the work of Elixhauser et al.;^12-14; and other medication exposures (benzodiazepines, opioids, acid-suppressive medications).