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Schematic of the multiscale cerebrovascular model coupling (a) a distributed 1D propagation network model for major systemic arteries and (b) a lumped parameter (LP) network for intracranial dynamics. Outflow in the 1D portion marked with open circles are coupled with the LP network in (right), and boundaries marked with closed circles are coupled to 3-element Windkessel models. The bounding box represents intracranial space. Adapted from34
