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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Nano Today. 2019 May 29;27:73–98. doi: 10.1016/j.nantod.2019.04.005

Table 4.

Inorganic NMs can be exploited to modulate or suppress inflammation in autoimmunity.

Immune Setting Inorganic NM Effect Ref.
Autoimmunity AuNPs Antigen and adjuvant delivery induced tolerance is models of MS and T1D 152
158
Peptide coating reduced disease severity in inflammatory bowel disease model 165
166
Iron oxide NPs Display of self-antigen in MHCs induced tolerance in models of T1D, MS, and arthritis. TREG expansion depended on dose and ligand density. 167
168
169
Inhibited TH1 cytokine expression in cells and reduced immune cell infiltration in a delayed-type hypersensitivity model 172
174
QDs Efficacy in a model of MS was dependent on self-antigen ligand dose and density 180