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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Trends Analyt Chem. 2019 Jul 5;117:242–262. doi: 10.1016/j.trac.2019.07.001

Figure 12.

Figure 12.

(A) Schematic illustration of enzyme-free quadratic amplification for detecting circulating miRNA based on hybridization chain reaction (HCR) and Ag+-mediated cascade SERS signal amplification. Ref. 154. Copyright 2015, The Royal Society of Chemistry. (B) Schematic of enzyme-free amplified detection of circulating exosomal miRNA with the assistance of the target-initiated HCR and DNAzyme. Ref. 156. Copyright 2018, The Royal Society of Chemistry. (C) Design scheme of photoluminescent biosensor for circulating microRNA detection based on self-assembled DNA cascades. Ref. 157. Copyright 2015, The Royal Society of Chemistry.