Table 1. Overview of breast cancer cell line characteristics.
Cell line | ATCC® No. | Type of tumour [30] | Original tissue [30] | Cell type [30] | ER status | PgR status | HER2 status | TP53[27] | Subtype | Ref. |
---|---|---|---|---|---|---|---|---|---|---|
MCF 10A | CRL-10317TM | NT | Fibrocystic disease | Epithelial | - | - | - | NT | [26, 27, 31] | |
MCF7 | HTB-22TM | AC | MS, PLE | Epithelial | + | + | - | Luminal | [6, 31–33] | |
T-47D | HTB-133TM | DC | MS, PLE | Epithelial | + | + | - | M | Luminal | [26, 27, 32, 34] |
CAMA-1 | HTB-21TM | AC | MS, PLE | WLELP | + | +/- | - | Luminal | [6, 26, 27] | |
MDA-MB-436 | HTB-130TM | AC | MS, PLE | PMMCC | - | - | - | TNBC | [6, 26, 27] | |
MDA-MB-231 | HTB-26TM | AC | MS, PLE | Epithelial like | - | - | - | M | TNBC | [16, 26, 27, 31, 33, 34] |
SK-BR-3 | HTB-30TM | AC | MS, PLE | Epithelial | - | - | + | HER2 | [6, 31–33] |
AC: adenocarcinoma, DC: ductal carcinoma, MS: metastatic site, PLE: pleural effusion, NT: Non-tumorigenic, PMMCC: Pleomorphic with multinucleated component cells, WLELP: weakly luminal epithelial-like phenotype. TP53 mutational status: M mutant protein.