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. 2020 Apr 14;15(4):e0231289. doi: 10.1371/journal.pone.0231289

Table 1. Overview of breast cancer cell line characteristics.

Cell line ATCC® No. Type of tumour [30] Original tissue [30] Cell type [30] ER status PgR status HER2 status TP53[27] Subtype Ref.
MCF 10A CRL-10317TM NT Fibrocystic disease Epithelial - - - NT [26, 27, 31]
MCF7 HTB-22TM AC MS, PLE Epithelial + + - Luminal [6, 3133]
T-47D HTB-133TM DC MS, PLE Epithelial + + - M Luminal [26, 27, 32, 34]
CAMA-1 HTB-21TM AC MS, PLE WLELP + +/- - Luminal [6, 26, 27]
MDA-MB-436 HTB-130TM AC MS, PLE PMMCC - - - TNBC [6, 26, 27]
MDA-MB-231 HTB-26TM AC MS, PLE Epithelial like - - - M TNBC [16, 26, 27, 31, 33, 34]
SK-BR-3 HTB-30TM AC MS, PLE Epithelial - - + HER2 [6, 3133]

AC: adenocarcinoma, DC: ductal carcinoma, MS: metastatic site, PLE: pleural effusion, NT: Non-tumorigenic, PMMCC: Pleomorphic with multinucleated component cells, WLELP: weakly luminal epithelial-like phenotype. TP53 mutational status: M mutant protein.