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Similar to GH, REG-O3 action displays a bell-shaped concentration dependence. When intra-articularly injected either at 5 μg or 50 μg, REG-O3 is inactive. The active range of intra-articularly injected REG-O3 spans from 7.5 μg to 42.5 μg where 25 μg represents the top of the bell.
