Table 2. Individual response data of mucosal thickness during treatment and follow-up period in the dose finding study.
| Subject number | Received dose P60.4Ac (mg/ml) | Mucosal thickness score during treatment and follow-up period (week)a 0 1 2 4 8 12 | |||||
|---|---|---|---|---|---|---|---|
| 01 | 0.25 | 2 | 1 | 1 | 0 | 0 | 1 b |
| 02 | 0.25 | 2 | 0 | 1 b | 0 | 0 | 0 |
| 03 | 0.25 | 3 | 1 | 1 | 1 | 0 | 0 |
| 04 | 0.25 | 3 | 2 | 1 | 1 | 2 | 2 |
| 05 | 0.5 | 3 | 1 | 1 | 2 | 2 | 2 |
| 06 | 0.5 | 1 | 1 | 0 | 0 | 0 | 0 |
| 07 | 0.5 | 2 | 2 | 1 | 0 | 0 | 0 |
| 08 | 0.5 | 1 | 1 | 2 | 1 | 0 | 1 |
| 09 | 1.0 | 3 | 1 | 0 | 0 | 0 | 0 |
| 10 | 1.0 | 3 | 2 | 2 | 1 | 0 | 0 |
| 11 | 1.0 | 3 | 2 | 2 | 3 | 2 | 2 |
| 12 | 1.0 | 3 | 2 | 2 | 2 | 3 | 2 |
| 13 | 2.0 | 2 | 1 | 2 | 2 | 2 | 2 |
| 14 | 2.0 | 2 | 2 | 2 | 2 | 1 | 3 |
| 15 | 2.0 | 3 | 3 | 2 | 1 | 2 | 0c |
| 16 | 2.0 | 2 | 1 | 1 | 3 | 2 | 2 |
a Scores: 0: flat, dry mucosa; 1: flat, discharging mucosa; 2: thickened, polypoid, dry or discharging mucosa; 3: thickened polypoid tissue with viscous mucous discharge.
b Subject had a cold at that time.
c Subject had used an antibiotic treatment for frontal sinusitis.