Table 5.

Risk of Large Classical Papillary Thyroid Cancer (>10 mm) Associated With Lipid-Corrected Serum Concentrations of Polybrominated Diphenyl Ether and Polybrominated Biphenyl Congeners (ng/g) Among Cases and Controls, Stratified by Sex, Department of Defense Cohort, United States, 2000–2013

Congener and Concentration	Male				Female				P for Interaction b
	No. of Cases a	No. of Controls a	OR b	95% CI	No. of Cases a	No. of Controls a	OR b	95% CI
BDE-28
<LOD	129	138	1.00	Referent	86	111	1.00	Referent
>LOD–1.56	25	21	1.50	0.69, 3.26	15	18	1.13	0.39, 3.30
1.57–3.18	26	25	2.07	0.86, 4.94	17	12	3.56	0.87, 14.63
3.19–80.10	26	20	3.39	0.98, 11.71	32	11	10.74	1.93, 59.72
P for trendc			0.071				0.0054		0.0040
BDE-47
<LOD–8.43	52	50	1.00	Referent	37	41	1.00	Referent
8.44–16.91	52	46	1.26	0.56, 2.82	32	46	1.43	0.57, 3.59
16.92–38.63	56	54	0.94	0.31, 2.87	31	27	3.08	0.79, 12.02
38.64–2,189.00	46	54	0.41	0.08, 2.12	50	38	0.67	0.07, 6.09
P for trendc			0.47				0.70		0.0095
BDE-85
<LOD	148	142	1.00	Referent	96	116	1.00	Referent
>LOD–1.68	25	23	0.56	0.21, 1.45	14	7	1.03	0.17, 6.40
1.69–3.18	11	21	0.28	0.08, 1.02	11	20	0.17	0.02, 1.49
3.19–79.08	22	19	0.40	0.07, 2.52	31	10	2.46	0.12, 51.74
P for trendc			0.065				0.50		0.0087
BDE-99
<LOD–2.17	54	47	1.00	Referent	40	40	1.00	Referent
2.18–4.40	51	50	0.89	0.39, 2.03	31	42	0.72	0.29, 1.81
4.41–10.61	52	52	1.02	0.34, 3.02	34	36	0.48	0.14, 1.61
10.62–993.30	49	56	1.00	0.24, 4.25	47	35	0.51	0.09, 2.85
P for trendc			0.92				0.33		0.036
BDE-100
<LOD–1.84	55	45	1.00	Referent	42	41	1.00	Referent
1.85–3.71	49	48	0.74	0.31, 1.77	33	47	0.58	0.21, 1.56
3.72–8.65	46	52	0.73	0.22, 2.35	24	30	0.43	0.10, 1.89
8.66–368.00	56	59	0.89	0.18, 4.36	51	34	0.91	0.09, 9.18
P for trendc			0.88				0.60		0.014
BDE-153
<LOD–2.49	48	32	1.00	Referent	50	54	1.00	Referent
2.50–4.61	45	49	0.78	0.40, 1.54	31	37	0.95	0.44, 2.07
4.62–11.23	51	55	0.82	0.38, 1.76	30	32	0.70	0.25, 1.96
11.24–285.50	62	69	0.59	0.23, 1.55	41	30	0.59	0.18, 1.91
P for trendc			0.39				0.50		0.077
BDE-154
<LOD	139	141	1.00	Referent	91	117	1.00	Referent
>LOD–1.60	28	22	2.57	0.98, 6.73	16	9	4.43	0.94, 20.80
1.61–3.11	18	24	2.59	0.69, 9.64	19	14	4.65	0.56, 38.40
3.12–66.22	21	17	3.45	0.52, 22.96	24	12	0.54	0.02, 13.54
P for trendc			0.061				0.40		0.0070
BB-153
<LOD–0.85	41	34	1.00	Referent	51	58	1.00	Referent
0.86–2.12	41	41	0.66	0.32, 1.35	47	43	0.84	0.44, 1.63
2.13–3.60	61	63	0.67	0.35, 1.27	29	32	0.83	0.40, 1.75
3.61–451.30	63	66	0.70	0.37, 1.34	23	19	0.99	0.42, 2.32
P for trendc			0.46				0.92		0.16

Abbreviations: BB-153, 2,2′,4,4′,5,5′-hexabromobiphenyl; BDE-28, 2,4,4′-tribromodiphenyl ether; BDE-47, 2,2′,4,4′-tetrabromodiphenyl ether; BDE-85, 2,2′,3,4,4′-pentabromodiphenyl ether; BDE-99, 2,2′,4,4′,5-pentabromodiphenyl ether; BDE-100, 2,2′,4,4′,6-pentabromodiphenyl ether; BDE-153, 2,2′,4,4′,5,5′-hexabromodiphenyl ether; BDE-154, 2,2′,4,4′,5,6′-hexabromodiphenyl ether; BMI, body mass index; CI, confidence interval; LOD: limit of detection; OR, odds ratio; PBB, polybrominated biphenyl; PBDE, polybrominated diphenyl ether.

^a Values in subgroups do not sum to the total due to nonreportable values.

^b Multichemical conditional logistic regression, adjusted for all PBDE and PBB congeners, BMI (calculated as weight (kg)/height (m)²: <18.5, 18.5–24.9, 25.0–29.9, ≥30.0, or missing), and branch of military service (Army, Air Force, Navy, and Marines/Coast Guard).

^c P values were not corrected for multiple comparison.