Adams 2004.

Methods	Design: parallel group randomized trial Duration of study: not reported Duration of follow‐up: 30 days
Participants	Country: Republic of South Africa Setting: school Number included in study: 150 Age: 6–16 years (mean 10 years) Sex: 75 girls, 75 boys Inclusion criteria: pupils at a primary school serving a wine‐producing area were eligible to receive albendazole if they were infested by T trichiura. Children not infected by any species of helminth were suitable for the placebo group. Exclusion criteria: chronic prescription medication, clinically evident illness, or both Lost at follow‐up: 37 (24.6%) Number positive for A lumbricoides: 58 Number included in review: 58
Interventions	Treatment strategy: screening and treat all included participants Group 1: albendazole 400 mg single dose (n = 15) Group 2: albendazole 400 mg 2 consecutive days (n = 22) Group 3: albendazole 400 mg 3 consecutive days (n = 21) Group 4: placebo (no randomized group; not included in the review)
Outcomes	Outcomes included:Ascaris prevalence pre‐ and post‐treatment cure rates and adverse events Outcomes not included in review: efficacy of anthelmintic treatment for T trichiura not reported
Notes	Diagnostic technique: "Standard methods" Funding support: The Peninsula School Feeding Association; Anglo American Chairman's Fund, AngloGold Fund, De Beers Fund, and AusAID supported operational and developmental research to implement crèche‐ and school‐based deworming, health education and sanitation in impoverished communities in the south‐western Cape. GlaxoSmithKline donated the albendazole and placebo tablets.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "A statistician operating independently of the researchers in the field used random permutations to allocate the 150 Trichuris infected children into 3 groups, which were again randomized to the different doses of albendazole."
Allocation concealment (selection bias)	Low risk	Quote: "Set of three blister packs for each code recipient were prepared in laboratory. Packs were marked for use on day 1, 2 and 3 respectively."
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Quote: "Placebo tablets matched the albendazole tablets in appearance, as did the blister packs. All treatments comprised 1 tablet a day for 3 days. At the school, neither the person administering the treatment, nor the child receiving the tablet, was aware of the dose."
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Faecal samples were coded and microscopist who processed and examined the specimens for helminth eggs were unaware which treatment group any sample corresponded to.
Incomplete outcome data (attrition bias) All outcomes	High risk	37 (24.7%) participants lost at follow‐up and not included in analysis.
Selective reporting (reporting bias)	Low risk	All stated outcomes reported.
Other bias	Low risk	No other obvious source of bias.