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. 2020 Apr 14;2020(4):CD010599. doi: 10.1002/14651858.CD010599.pub2

Jongsuksuntigul 1993.

Methods Design: parallel group randomized trial
Duration of study: 5–30 August 1991
Follow‐up: 14 days
Participants Country: Thailand Kingdom
Setting: community
Number included in study: 196
Age: 3–80 years
Sex: 98 male, 98 female
Inclusion criteria: single or multiple infections of hookworm, Ascaris, and Trichuris
Exclusion criteria: pregnant women and breastfeeding mothers
Lost at follow‐up: 0 (0%)
Number positive for A lumbricoides: 56
Number included in review: 56
Interventions Treatment strategy: screening and treat all included participants
  • Group 1: mebendazole 300 mg single dose (original) (n = 12)

  • Group 2: mebendazole 300 mg single dose (n = 14)

  • Group 3: mebendazole 500 mg single dose (n = 17)

  • Group 4: albendazole 400 mg single dose (n = 13)

Outcomes Outcomes included:Ascaris prevalence pre‐ and post‐treatment, cure rates, pre‐ and post‐treatment GM epg, ERR adverse events
Outcomes not included in review: anthelmintic efficacy for hookworm, Trichuris, andEnterobius
Notes Diagnostic technique: Kato‐Katz
Funding support: SmithKline Beecham Pharmaceuticals Ltd and Janssen Pharmaceutica Ltd
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Details not reported.
Quote: "patients were randomly assigned into four treatment groups."
Allocation concealment (selection bias) Unclear risk Details not reported.
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Drugs had different appearance.
Blinding of outcome assessment (detection bias) 
 All outcomes Low risk Quote: "The laboratory technicians were blind to the respective treatment of each patient group."
Incomplete outcome data (attrition bias) 
 All outcomes Low risk All randomized participants included in analysis.
Selective reporting (reporting bias) Low risk All stated outcomes were reported.
Other bias Unclear risk Pharmaceutical support unclear.