Jongsuksuntigul 1993.
Methods |
Design: parallel group randomized trial Duration of study: 5–30 August 1991 Follow‐up: 14 days |
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Participants |
Country: Thailand Kingdom Setting: community Number included in study: 196 Age: 3–80 years Sex: 98 male, 98 female Inclusion criteria: single or multiple infections of hookworm, Ascaris, and Trichuris Exclusion criteria: pregnant women and breastfeeding mothers Lost at follow‐up: 0 (0%) Number positive for A lumbricoides: 56 Number included in review: 56 |
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Interventions |
Treatment strategy: screening and treat all included participants
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Outcomes |
Outcomes included:Ascaris prevalence pre‐ and post‐treatment, cure rates, pre‐ and post‐treatment GM epg, ERR adverse events Outcomes not included in review: anthelmintic efficacy for hookworm, Trichuris, andEnterobius |
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Notes |
Diagnostic technique: Kato‐Katz Funding support: SmithKline Beecham Pharmaceuticals Ltd and Janssen Pharmaceutica Ltd |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Details not reported. Quote: "patients were randomly assigned into four treatment groups." |
Allocation concealment (selection bias) | Unclear risk | Details not reported. |
Blinding of participants and personnel (performance bias) All outcomes | High risk | Drugs had different appearance. |
Blinding of outcome assessment (detection bias) All outcomes | Low risk | Quote: "The laboratory technicians were blind to the respective treatment of each patient group." |
Incomplete outcome data (attrition bias) All outcomes | Low risk | All randomized participants included in analysis. |
Selective reporting (reporting bias) | Low risk | All stated outcomes were reported. |
Other bias | Unclear risk | Pharmaceutical support unclear. |