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. 2020 Apr 14;2020(4):CD010599. doi: 10.1002/14651858.CD010599.pub2

Legesse 2002.

Methods Design: parallel group randomized trial
Duration of study: November 2000
Follow‐up: 21 days
Participants Country: Ethiopia
Setting: community
Number included in study: 520
Age: 2–80 years
Sex: 221 male, 299 female
Inclusion criteria: not reported
Exclusion criteria: not reported
Lost at follow‐up: 52 (11.0%)
Number positive for A lumbricoides: 387
Number included in review: 387
Interventions Treatment strategy: screening and treat all included participants
  • Group 1: mebendazole 100 mg twice a day for 3 days (n = 153)

  • Group 2: albendazole 400 mg single dose (n = 234)

Outcomes Outcomes included:Ascaris prevalence pre‐ and post‐treatment, cure rates, pre‐ and post‐treatment GM epg, ERR, adverse events
Outcomes not included in review: anthelmintic efficacy for Trichuris andS mansoni
Notes Diagnostic technique: Kato‐Katz
Funding support: not reported
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Quote: "A sequentially numbered list of individuals positive for Ascaris lumbricoides and/or Trichuris trichiura infections was prepared. The list was randomly divided into treatment group using random numbers obtained from a random number table."
Allocation concealment (selection bias) Unclear risk Details not reported.
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Different treatment schedule.
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk Details not reported.
Incomplete outcome data (attrition bias) 
 All outcomes Low risk 52 (11.0%) participants lost at follow‐up and not included in analysis.
Selective reporting (reporting bias) Low risk All stated outcome were reported.
Other bias Low risk No other obvious source of bias.