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. 2020 Apr 14;2020(4):CD010599. doi: 10.1002/14651858.CD010599.pub2

Stephenson 1989.

Methods Design: parallel group randomized trial
Duration of study: 1989
Follow‐up: 180 days
Participants Country: Kenya
Setting: school
Number included in study: 17
Age: 6–16 years
Sex: 96 boys, 75 girls
Inclusion criteria: all available children in the lower grades (Standards I and II) in Mvindeni Primary School in Kwale District, Coast Province, Kenya
Exclusion criteria: severe anaemia at stool examination 1 (haemoglobin < 8.0 g/dL)
Lost at follow‐up: 21 (12.3%)
Number positive for A lumbricoides: 73
Number included in review: 73
Interventions Treatment strategy: screening and treat all included participants
  • Group 1: albendazole 200 mg 2 tablets single dose (n = 34)

  • Group 2: placebo (n = 39)

Outcomes Outcomes included:Ascaris prevalence pre‐ and post‐treatment, AM and GM epg
Outcomes not included in review: anthropometric measures, anthelmintic efficacy for T trichiura and hookworm
Notes Diagnostic technique: modified Kato‐Katz
Funding support: Smith Kline & French Laboratories, Ltd., and the Edna McConnellClark Foundation
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Quote: "the children were allocated at random within sex to albendazole (A) or placebo (PL) groups and treated."
Allocation concealment (selection bias) Unclear risk Details not reported.
Blinding of participants and personnel (performance bias) 
 All outcomes Low risk Quote: "Control group received identical placebo."
Blinding of outcome assessment (detection bias) 
 All outcomes Low risk Quote: "examinations were carried out with the same team of worker and were done in a blind fashion."
Incomplete outcome data (attrition bias) 
 All outcomes Low risk 21 (12.3%) participants lost at follow‐up and not included in analysis.
Selective reporting (reporting bias) High risk Adverse events not reported.
Other bias Unclear risk Financial support: Smith Kline & French Laboratories, Ltd.