Stephenson 1989.
Methods |
Design: parallel group randomized trial Duration of study: 1989 Follow‐up: 180 days |
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Participants |
Country: Kenya Setting: school Number included in study: 17 Age: 6–16 years Sex: 96 boys, 75 girls Inclusion criteria: all available children in the lower grades (Standards I and II) in Mvindeni Primary School in Kwale District, Coast Province, Kenya Exclusion criteria: severe anaemia at stool examination 1 (haemoglobin < 8.0 g/dL) Lost at follow‐up: 21 (12.3%) Number positive for A lumbricoides: 73 Number included in review: 73 |
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Interventions |
Treatment strategy: screening and treat all included participants
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Outcomes |
Outcomes included:Ascaris prevalence pre‐ and post‐treatment, AM and GM epg Outcomes not included in review: anthropometric measures, anthelmintic efficacy for T trichiura and hookworm |
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Notes |
Diagnostic technique: modified Kato‐Katz Funding support: Smith Kline & French Laboratories, Ltd., and the Edna McConnellClark Foundation |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Quote: "the children were allocated at random within sex to albendazole (A) or placebo (PL) groups and treated." |
Allocation concealment (selection bias) | Unclear risk | Details not reported. |
Blinding of participants and personnel (performance bias) All outcomes | Low risk | Quote: "Control group received identical placebo." |
Blinding of outcome assessment (detection bias) All outcomes | Low risk | Quote: "examinations were carried out with the same team of worker and were done in a blind fashion." |
Incomplete outcome data (attrition bias) All outcomes | Low risk | 21 (12.3%) participants lost at follow‐up and not included in analysis. |
Selective reporting (reporting bias) | High risk | Adverse events not reported. |
Other bias | Unclear risk | Financial support: Smith Kline & French Laboratories, Ltd. |