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. 2020 Apr 14;2020(4):CD010599. doi: 10.1002/14651858.CD010599.pub2

Stephenson 1993.

Methods Design: parallel group randomized trial
Duration of study: September 1989 to July 1990
Follow‐up: 108 days
Participants Country: Kenya
Setting: school
Number included in study: 328
Age: mean 10.5 years
Sex: not reported
Inclusion criteria: all available children in the lower grades (Standards I–V) in Mvindeni Primary School in Kwale District, Coast Province, Kenya
Exclusion criteria: children with heavy hookworm egg counts (> 20,000 epg of faeces) at examination 1 or 2
Lost at follow‐up: 44 (13.4%)
Number positive for A lumbricoides: 89
Number included in review: 89
Interventions Treatment strategy: screening and treat all included participants
  • Group 1: albendazole 200 mg 3 tablets (600 mg) single dose (n = 59)

  • Group 2: placebo (n = 30)

Outcomes Outcomes included:Ascaris prevalence pre‐ and post‐treatment, AM and GM epg
Group 1 and 2 analysed together in review after the first round of treatment
Outcomes not included in review: outcomes after the second round of treatment, anthropometric measures, anthelmintic efficacy for T trichiura and hookworm
Notes Diagnostic technique: modified Kato‐Katz
Funding support: supported in part by Thrasher Research Fund and SmithKline Beecham, Ltd.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Quote: "At exam 1, children were allocated at random within sex by descending hookworm egg count to placebo one dose or two dose groups."
Allocation concealment (selection bias) Unclear risk Details not reported.
Blinding of participants and personnel (performance bias) 
 All outcomes Low risk Identical placebo.
Blinding of outcome assessment (detection bias) 
 All outcomes Low risk Quote: "examinations were carried out with the same team of workers and were done in a blind fashion."
Incomplete outcome data (attrition bias) 
 All outcomes Low risk 44 (13.4%) participants lost at follow‐up and not included in analysis.
Selective reporting (reporting bias) High risk Adverse events not reported.
Other bias Unclear risk Quote: "Supported in part by Thrasher Research Fund and SmithKline Beecham, Ltd."