Stephenson 1993.
Methods |
Design: parallel group randomized trial Duration of study: September 1989 to July 1990 Follow‐up: 108 days |
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Participants |
Country: Kenya Setting: school Number included in study: 328 Age: mean 10.5 years Sex: not reported Inclusion criteria: all available children in the lower grades (Standards I–V) in Mvindeni Primary School in Kwale District, Coast Province, Kenya Exclusion criteria: children with heavy hookworm egg counts (> 20,000 epg of faeces) at examination 1 or 2 Lost at follow‐up: 44 (13.4%) Number positive for A lumbricoides: 89 Number included in review: 89 |
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Interventions |
Treatment strategy: screening and treat all included participants
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Outcomes |
Outcomes included:Ascaris prevalence pre‐ and post‐treatment, AM and GM epg Group 1 and 2 analysed together in review after the first round of treatment Outcomes not included in review: outcomes after the second round of treatment, anthropometric measures, anthelmintic efficacy for T trichiura and hookworm |
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Notes |
Diagnostic technique: modified Kato‐Katz Funding support: supported in part by Thrasher Research Fund and SmithKline Beecham, Ltd. |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Quote: "At exam 1, children were allocated at random within sex by descending hookworm egg count to placebo one dose or two dose groups." |
Allocation concealment (selection bias) | Unclear risk | Details not reported. |
Blinding of participants and personnel (performance bias) All outcomes | Low risk | Identical placebo. |
Blinding of outcome assessment (detection bias) All outcomes | Low risk | Quote: "examinations were carried out with the same team of workers and were done in a blind fashion." |
Incomplete outcome data (attrition bias) All outcomes | Low risk | 44 (13.4%) participants lost at follow‐up and not included in analysis. |
Selective reporting (reporting bias) | High risk | Adverse events not reported. |
Other bias | Unclear risk | Quote: "Supported in part by Thrasher Research Fund and SmithKline Beecham, Ltd." |