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. 2020 Apr 14;2020(4):CD010599. doi: 10.1002/14651858.CD010599.pub2

Wen 2008.

Methods Design: parallel group randomized trial
Duration of study: not reported
Follow‐up: 30 days
Participants Country: People's Republic of China
Setting: community (multicentre)
Age: 6–70 years
Sex: 79 male, 125 female
Number included in study: 816
Inclusion criteria: faecal egg‐positive farmers and children > 6 years of age from rural areas
Exclusion criteria: other diseases such as hepatic, renal, and cardiovascular diseases; and pregnant or lactating women
Follow‐up: 0 (0%)
Number positive for A lumbricoides: 204
Number included in review: 204
Interventions Treatment strategy: screening and treat all included participants
  • Group 1: ivermectin 0.1 mg/kg (1 tablet) single dose (n = 102)

  • Group 2: albendazole 6.7 mg/kg (2 tablets) single dose (n = 102)

Outcomes Outcomes included:Ascaris prevalence pre‐ and post‐treatment, cure rates, pre‐ and post‐treatment AM epg, ERR, adverse events
Outcomes not included in review: anthelmintic efficacy for Trichuris, hookworm, and Enterobius vermicularis
Notes Diagnostic technique: Kato‐Katz
Funding support: World Health Organization
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Quote: "individuals confirmed with intestinal nematode infections were chosen and stratified by age, sex, and intensity of the infection, and then were randomly assigned into treatment groups."
Allocation concealment (selection bias) Unclear risk Details not reported.
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Treatment drugs had different appearance.
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk Details not reported.
Incomplete outcome data (attrition bias) 
 All outcomes Low risk All participants included in analysis.
Selective reporting (reporting bias) Low risk All stated outcomes were reported.
Other bias Low risk No obvious source of other bias.