Table 2.

Summary of histological findings of COVID-19.

Patients	Lung	Liver	Heart
1	Acute-phase DAD: hyaline membrane; focal sloughing of pneumocytes alternating with type II pneumocyte hyperplasia and syncytial giant cells formation; focal lymphocytic infiltration (changes of CLL)	Nuclear glycogenation in hepatocyte; focal mild macrovesicular steatosis, neoplastic lymphocytic accumulation in portal tracts; ductopenia in some portal tracts	Focal mild edema, interstitial fibrosis, and myocardial hypertrophy; no inflammatory cellular infiltration
2	Acute-phase DAD: mainly hyaline membranes formation	Cirrhosis (pre-existing); specimen too limited for further evaluation	Not sampled
3	Acute-phase DAD predominant: hyaline membrane; focal interstitial thickening, vascular congestion, mild inflammatory cellular infiltration	Mild zone 3 sinusoidal dilatation, patchy hepatic necrosis, mild increase in sinusoidal lymphocytes	Not sampled
4	Organizing-phase DAD: hyaline membrane; intra-alveolar hemorrhages, early organization, interstitial thickening, focal fibrinoid necrosis of small vessel wall, abundant intra-alveolar neutrophilic infiltration	Mild zone 3 sinusoidal dilatation, patchy hepatic necrosis in periportal area and centrilobular area, Kupffer cells hyperplasia in focal sinusoids, mild increase in sinusoidal lymphocytes, scanty lymphocytes in the portal tracts	Similar to patient #1

DAD diffuse alveolar damage.