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Does it work to prevent infection?
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Decrease in confirmed infections in a cohort of uninfected individuals |
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Pre- and post-exposure prophylaxis
|
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Does it work to prevent clinical disease?
|
Decrease in proportion of patients that develop clinical symptoms |
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Clinical disease prevention
|
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Does it work to prevent clinical severity?
|
Decrease in proportion of patients with onset of severe disease (SARS criteria, need for respiratory support, ICU admission, post-infection respiratory sequelae) |
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Severe clinical disease prevention
|
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Does it work to prevent death?
|
Reduced mortality in severe cases (hospitalized patients) |
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Mortality prevention
|
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Does it decrease viral load in blood and secretions?
|
Rapid viral clearance after treatment |
|
Viral load
|
