Table 3.

Linear Regression to Evaluate the Potential Association Between CSF VILIP-1 and APOE ε4 Status in the Elderly (Unadjusted and Adjusted)

	Model 1		Model 2		Model 3		Model 4		Model 5
	Beta	P	Beta	P	Beta	P	Beta	P	Beta	P
APOE ε4 (+) vs. (-)	0.350	<0.001	0.344	<0.001	0.298	0.003	0.137	0.050	0.144	0.049
Age			−0.080	0.390	−0.061	0.526	−0.038	0.515	−0.044	0.484
Gender			0.208	0.033	0.211	0.035	0.027	0.659	0.032	0.633
Education			0.064	0.507	0.050	0.605	−0.042	0.48	−0.039	0.528
MMSE					0.069	0.537	0.042	0.539	0.045	0.518
CDR-SB					−0.010	0.929	0.010	0.889	0.006	0.936
RAVLT-immediate recall					0.020	0.907	0.054	0.607	0.062	0.574
RAVLT-delayed recall					−0.215	0.218	−0.101	0.346	−0.107	0.325
CSF Aβ42							0.314	<0.001	0.306	<0.001
CSF P-tau							0.776	<0.001	0.772	<0.001
Hippocampus									−0.033	0.691
Entorhinal									0.042	0.584

Notes: Model 1: unadjusted; Model 2: adjusted by age, gender, education; Model 3: adjusted by age, gender, education, MMSE, CDR-SB, RAVLT-immediate recall and RAVLT-delayed recall; Model 4: adjusted by age, gender, education, MMSE, CDR-SB, RAVLT-immediate recall, RAVLT-delayed recall, CSF Aβ42 and P-tau; Model 5: adjusted by age, gender, education, MMSE, CDR-SB, RAVLT-immediate recall, RAVLT-delayed recall, CSF Aβ42, P-tau, volumes of hippocampus and entorhinal cortex. Beta is standardized beta.

Abbreviations: CDR-SB, global clinical dementia rating scale; MMSE, mini-mental state examination; RAVLT, rey auditory verbal learning test.