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. Author manuscript; available in PMC: 2020 Apr 14.
Published in final edited form as: Helv Chim Acta. 2019 Apr 1;102(4):e1900033. doi: 10.1002/hlca.201900033

Table 1.

Suzuki cross-coupling performed on aryl iodide and aryl bromide DNA conjugates. The reactions were carried out at 60 °C for 3 hours using 0.4 eq. of Pd(OAc)2 - TPPTS complex as catalyst. The reported conversions were calculated by integrating UPLC chromatograms of crude reactions.

Reactants vs. Substrate graphic file with name EMS85568-i006.jpg graphic file with name EMS85568-i007.jpg
graphic file with name EMS85568-i008.jpg 0% 0%
graphic file with name EMS85568-i009.jpg 88% 0%
graphic file with name EMS85568-i010.jpg >98% 60%
graphic file with name EMS85568-i011.jpg >98% 40%
graphic file with name EMS85568-i012.jpg >98% 40%
graphic file with name EMS85568-i013.jpg >98% 50%
graphic file with name EMS85568-i014.jpg 70% 0%
graphic file with name EMS85568-i015.jpg 70% 0%