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. Author manuscript; available in PMC: 2020 Apr 14.
Published in final edited form as: Helv Chim Acta. 2019 Apr 1;102(4):e1900033. doi: 10.1002/hlca.201900033

Table 3. Screening of different catalysts, substrates and reaction conditions for Suzuki and Sonogashira “on-DNA” cross-couplings.

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Pd(II)
Source		 Cu(II)
Source		 Monitored after Temp. Eq. of Pd [a]
Pd(Oac)2 Cu(Oac)2 10 mins 50 °C 0.2
PdCl2 Cu(SO4)2 1 hour 60 °C 0.5
PdCl2(PPh3)2 Cu(Otf)2 2 hours 65 °C 1.0
[PdCl(allyl)]2 Cu(Oac)2L 4 hours 70 °C 1.5
Copper-free 24 hours 2.0
4.0
[a]

Equivalents with respect to DNA - aryl halide conjugate (3).