Table 1.

Definitions of the primary efficacy outcome in each of the included trials

Trial	Definition of primary efficacy outcome
CHANCE 2013	Stroke recurrence (ischemic or hemorrhagic).
CHARISM 2006	The composite of myocardial infarction, stroke, or death from cardiovascular causes.
CREDO 2002	The composite of death, myocardial infarction, and stroke.
CURE 2001	The composite of myocardial infarction, stroke, or death from cardiovascular causes.
POINT 2018	The composite of ischemic stroke, myocardial infarction, or death from ischemic vascular causes.
SPS3 2012	Stroke recurrence (ischemic or hemorrhagic).