Table 2.
Characteristics of the excluded trials
| Title | Reason for exclusion |
| A randomised, blinded, trial of clopidogrel vs aspirin in patients at risk of ischaemic events (CAPRIE) | Not clopidogrel + aspirin vs aspirin |
| Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation | Treatment duration < 3 mo; Not report subgroup results |
| Addition of clopidogrel to aspirin in 45852 patients with acute myocardial infarction: Randomised placebo-controlled trial | Treatment duration < 3 mo; Not report subgroup results |
| Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): Randomised, double-blind, placebo-controlled trial | Not clopidogrel + aspirin vs aspirin |
| Aspirin and extended-release dipyridamole vs clopidogrel for recurrent stroke | Not clopidogrel + aspirin vs aspirin |
| Aspirin plus clopidogrel therapy increases early venous graft patency after coronary artery bypass surgery | Treatment duration < 3 mo |
| Aspirin plus clopidogrel vs aspirin alone after coronary artery bypass grafting: The clopidogrel after surgery for coronary artery disease (CASCADE) Trial | Not report subgroup results |
| Clinical outcomes of patients with diabetic nephropathy randomized to clopidogrel plus aspirin vs aspirin alone | Duplicate trials |
| Clopidogrel with aspirin in acute minor stroke or transient ischemic attack (CHANCE) trial: One year outcomes | Duplicate trials |
| Dose comparisons of clopidogrel and aspirin in acute coronary syndromes | High dose vs low dose |
| Duration of Dual Antiplatelet Therapy after Implantation of Drug-Eluting Stents | Long-term vs short-term |
| Efficacy and safety outcomes of ticagrelor compared with clopidogrel in elderly Chinese patients with acute coronary syndrome | Not clopidogrel + aspirin vs aspirin |
| Effect of clopidogrel pretreatment before percutaneous coronary intervention in patients with ST-elevation myocardial infarction treated with fibrinolytics | Treatment duration < 3 mo |
| Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: The PCI-CURE study | Duplicate trials |
| Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): A randomised controlled pilot trial | Not report subgroup results |
| Prasugrel or double-dose clopidogrel to overcome clopidogrel low-response – The TAILOR randomized trial | Not clopidogrel + aspirin vs aspirin |
| Prasugrel vs clopidogrel for acute coronary syndromes without revascularization | Not clopidogrel + aspirin vs aspirin |
| Prasugrel vs clopidogrel in patients with acute coronary syndromes | Not clopidogrel + aspirin vs aspirin |
| PROCLAIM: Pilot study to examine the effects of clopidogrel on inflammatory markers in patients with metabolic syndrome receiving low-dose aspirin. | Treatment duration < 3 mo |
| Randomized clinical trial of the antiplatelet effects of aspirin-clopidogrel combination vs aspirin alone after lower limb angioplasty | Treatment duration < 3 mo |
| Randomized comparison of prasugrel (CS-747, LY640315), a novel thienopyridine P2Y12 antagonist, with clopidogrel in percutaneous coronary intervention | Not clopidogrel + aspirin vs aspirin |
| Results of the randomized, placebo-controlled clopidogrel and acetylsalicylic acid in bypass surgery for peripheral arterial disease (CASPAR) trial | Not report subgroup results |
| Ticagrelor vs aspirin in acute stroke or transient ischemic attack | Not clopidogrel + aspirin vs aspirin |
| Ticagrelor vs clopidogrel in patients with acute coronary syndromes | Not clopidogrel + aspirin vs aspirin |
| Ticagrelor vs clopidogrel after fibrinolytic therapy in patients with ST-elevation myocardial infarction | Not clopidogrel + aspirin vs aspirin |
| Ticagrelor vs. clopidogrel in Japanese, Korean and Taiwanese patients with acute coronary syndrome | Not clopidogrel + aspirin vs aspirin |
| Twelve or 30 mo of dual antiplatelet therapy after drug-eluting stents | Long-term vs short-term |
| Effect of Clopidogrel Added to Aspirin in Patients with Atrial Fibrillation | Not ACS or ischemic stroke patients |