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. Author manuscript; available in PMC: 2020 Apr 15.
Published in final edited form as: Curr Opin Struct Biol. 2019 Nov 18;61:17–24. doi: 10.1016/j.sbi.2019.10.001

Figure 2.

Figure 2

Changes in TBP binding partners through the process of promoter binding. On the top are the atomic structures of human TFIID in the process of promoter engagement. With (a) in the canonical state, (b) in the scanning state and (c) in the engaged state. On the bottom, (d) shows TBP bound by inhibitory TAFs, (e) how these TAFs act to inhibit DNA binding and (f) how TBP binds the general transcription factors TFIIA and TFIIB when in complex with the PIC. The engaged TFIID complex recruits Pol II (g) with the aid of TFIIB and TFIIF.