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. Author manuscript; available in PMC: 2020 Apr 15.
Published in final edited form as: Curr Opin Struct Biol. 2019 Nov 18;61:17–24. doi: 10.1016/j.sbi.2019.10.001

Figure 3.

Figure 3

Possible model of human TFIID assembly. A number of TFIID subcomplexes initially assemble in the cytoplasm (5TAF: TAF4, 5, 6, 9, 12; cTAF: TAF2, 8, 10; sTAF: TAF1, 7, 11, 13 and TBP; TAF3/10) and can enter the nucleus due to the presence of nuclear localization signal sequences on TAF4, TAF8, TAF1 and TAF3. The final stages of TFIID assembly likely occur in the nucleus. We propose that the binding of either cTAF or TAF3/10 to the 5TAF leads to two different core subcomplexes, bcTAF and aTAF, respectively. Once the bcTAF and aTAF subcomplexes heterodimerize, they can then interact with the sTAF subcomplex to complete the assembly of TFIID.